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Re: Is there an updated list?

Posted by SLS on February 8, 2003, at 11:40:10

In reply to Re: Is there an updated list?, posted by Peter S. on February 7, 2003, at 14:14:04

> Yeah that's true. But some of them seem to be up to date- like it says that duloxetine has been submitted. It's confusing.
> > Maybe I am not looking at the right place, but it seems that it is out of date as lexapro and effexor XR are not approved according to the chart. I wonder what phase things are in at this time?


I contacted Eli Lilly last week regarding the approval status of duloxetine (Cymbalta). The FDA granted Lilly an "approvable letter", which is one step away from full approval. It seems that the only thing left for the FDA to examine is the manufacturing facility. Sometimes the wording of the label (package insert) remains as the last obstacle. In any event, as of last week, duloxetine had not started production. Soon, hopefully. It is at the top of my list. In the interim, I don't know if I should just wait and give my poor brain a chance to catch its breath after these recent drug trials. Otherwise, I guess Lexapro would be my next choice; combined with desipramine at first, and perhaps switching from desipramine to Strattera.

I know it is tempting to feel smart by using our very limited understanding of the brain and what drugs do once they get inside it so as to predict the usefulness of any given drug. Obviously, some people show trends in their reactions to drugs within a class. However, one never knows. I recently witnessed someone whom was severely depressed with pronounced psychomotor retardation. Over the last two years of treatment, he failed to respond to Prozac, Zoloft, and Celexa. It's a good thing he wasn't educated enough to decline his doctor's recommendation to try Paxil next. He has attained full remission.

During a consultation with Patrick McGrath, MD at Columbia University, he told me quite simply that for every new drug that becomes available, a certain percentage of previously refractory cases of depression and bipolar disorder will respond and go on to lead healthy lives. To hear this has helped me to resist better occasional paroxysmal bouts of suicidal ideation.

I know at least one person who does better on Lexapro than he does on Celexa. I can't help but to have at least some hope that I'll get lucky with one of the new medications that have come out over the last 6 months.

After duloxetine and gepirone come to market, I am unaware of any other antidepressants close to obtaining FDA approval.

Is anyone aware of other antidepressants in phase III or close to being approved?

- Scott




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