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Cybercafe + misc DA blocker tardive disorder news

Posted by action_jackson on September 2, 2002, at 10:27:10

In reply to APS - EPS » action_jackson, posted by cybercafe on September 1, 2002, at 17:33:12

Cybercafe -

Parkinson's Disease patients are good examples of those who really are supposed to avoid all atypicals. Only clozapine does not apparently worsen Parkinson's - but also does not seem to benefit too many with Parkinson's + something else like psychosis which might call for an atypical.

The old DA blockers - it is known that even skitzophrenics who have HUGE tolerance for the effects of DA blockers and tolerate HUGE doses taken daily - even they will often (I think usually) get Tardive Dyskinesia after use for several years. And in these patients - the problem may not really be known until it occurs while they are still taking the A/P - meaning off the A/P the problem is worse - they must continue the A/P simply to avoid more severe movements - which are chronic and persistent and disfiguring.

Well a lot of different movements including classic TD occur in non-skitzophrenics - only are probably much more likely to occur more quickly and at lower doses. I see some info that there is no proof in fact that low doses are necessarily much safer than high doses in - and also that it is thought that intermittent use of DA blockers may be more damaging than ongoing.

The longer the use of any DA blocker - any movmeent disorders existing tends to get worse not better (reports of atypicals helping movements -- these are compared to older drugs - or as a "mask" compared to no drugs - discontinuation results in movements worse than with treatment - at least certainly in all tardive hyperkinetic movements beyond "classic TD" which is most common in those with skitzophrenia taking a/p's for years .. they are more immune to hyperkinetic disorders maybe due to abnormally high dopamine levels?? don't know why but seems to be the case that they mostly get "classic TD" - the type mostly seen before we started giving these drugs to other types of patients).

In all the treatment resistant people reporting here - how many seemed maintained on long term - many year atypical use? Seems to me I see people talking about shorter trials - still often resulting in abnormal movements at least for a short time if not more chronically.

Moclobomide and Parnate are good a/d's and serotonin and dopamine agonists - both are activating and aren't really anti-anxiety at least not much. Zyprexa is kind of opposite except than can also give antidepressant effect - but is a tranquilizer - anti anxiety, and serotnoin and dopamine blocker. Mostly opposite of moclobomide and parnate.

SSRI like Zoloft is antidepressant and mostly depletes dopamine (kind of zyprexa like effect) - except does not block serotonin. Adding serzone to Zoloft can reduce anxiety more - maybe boost antianxiety effect. Actually only time I really cared for serzone was when I tried adding 300 to the 50 zoloft I was trying out.


Chad
http://www.socialfear.com/

> .... so zyprexa is an awesome drug for me, in terms of primary effect, ... i am hoping these side effects (pin pricks + dystonia?) are only temporary, .... if my doc says they don't go away, i'd like to go off it..... don't know what i'd try to decrease activity in neocortex .... perhaps just switch parnate to moclobemide ? ... i really wish i could get my hands on a selective 5ht2 antagonist ....
>
> do you have a reason to believe zyprexa is as bad as risperdal or amisulpide actionjackson?
>
> anyways... hope you can get rid of your neurological problems.... with a stimulant? ... or ECT? ...


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URL: http://www.dr-bob.org/babble/20020829/msgs/118528.html