Posted by dr. dave on August 20, 2002, at 16:02:00
In reply to Re: Citalopram pharmacology -Dr. Dave » pharmrep, posted by Ritch on August 20, 2002, at 13:10:54
A study HAS been done on receptor affinity profiling for r- and s-citalopram separately. It is at http://www.cipralex.ch/pdf/poster/sobp_500.pdf
Note that the receptor affinities of r-citalopram are described as 'weak'.
I am reading that Lexapro doesn't cause somnolence - how does this fit with the fact that when study results have been combined, 1.9% of those on placebo complained of somnolence and 6% of those on Lexapro did? This is over three times as common. This gives you an idea of how the facts are being played around with here.
> > NO.....10mg Lex is 40mg of Celexa...trust me.
>
> PharmRep,
>
> I wished somebody would do receptor affinity profiling for r- and s- citalopram separately. If the r- isomer has little affinity for the serotonin reuptake transporter, it (the r-isomer) possibly could have an increased affinity for other receptors involved with side effects. I did find it interesting in the micromedex link posted a while ago that the half-life of s-citalopram is about 22 hrs and that the half-life of s+r-citalopram is about 35 hrs. (If that is inaccurate-please somebody correct me).
>
>
> thanks,
>
> Mitch
poster:dr. dave
thread:109458
URL: http://www.dr-bob.org/babble/20020814/msgs/117148.html