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Receptor affinity profiles of s- and r-citalopram

Posted by dr. dave on August 20, 2002, at 16:02:00

In reply to Re: Citalopram pharmacology -Dr. Dave pharmrep, posted by Ritch on August 20, 2002, at 13:10:54

A study HAS been done on receptor affinity profiling for r- and s-citalopram separately. It is at

Note that the receptor affinities of r-citalopram are described as 'weak'.

I am reading that Lexapro doesn't cause somnolence - how does this fit with the fact that when study results have been combined, 1.9% of those on placebo complained of somnolence and 6% of those on Lexapro did? This is over three times as common. This gives you an idea of how the facts are being played around with here.

> > NO.....10mg Lex is 40mg of me.
> PharmRep,
> I wished somebody would do receptor affinity profiling for r- and s- citalopram separately. If the r- isomer has little affinity for the serotonin reuptake transporter, it (the r-isomer) possibly could have an increased affinity for other receptors involved with side effects. I did find it interesting in the micromedex link posted a while ago that the half-life of s-citalopram is about 22 hrs and that the half-life of s+r-citalopram is about 35 hrs. (If that is inaccurate-please somebody correct me).
> thanks,
> Mitch




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