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your wish is granted Ritch

Posted by pharmrep on August 20, 2002, at 15:13:03

In reply to Re: Citalopram pharmacology -Dr. Dave pharmrep, posted by Ritch on August 20, 2002, at 13:10:54

> > NO.....10mg Lex is 40mg of me.
> PharmRep,
> I wished somebody would do receptor affinity profiling for r- and s- citalopram separately. If the r- isomer has little affinity for the serotonin reuptake transporter, it (the r-isomer) possibly could have an increased affinity for other receptors involved with side effects. I did find it interesting in the micromedex link posted a while ago that the half-life of s-citalopram is about 22 hrs and that the half-life of s+r-citalopram is about 35 hrs. (If that is inaccurate-please somebody correct me).
> thanks,
> Mitch

** hi Mitch...look this one is a study that compares r-citalopram, s-citalopram and celexa (which is both combined). This is proof that Lexapro is more than just 1/2 of Celexa.
c. Sanchez, H. Loft, SA Montgomery Pharmacol Toxicol May 2001; 88(5): 282-286
PS Celexa half-life is 35hrs...Lexapro has a range of 27-32.




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