Posted by Shawn. T. on July 20, 2002, at 23:50:46
In reply to trimipramine (anti-histamine vs. anti-cholenergic) » katekite, posted by fachad on July 20, 2002, at 17:07:44
Note that you'll lose the anti-histamine
side effects after a couple weeks. Your body develops a tolerance over the course of a couple weeks I believe. Note that these binding values are not in vivo.SSRI histamine (H1) binding values:
Prozac: 470
Zoloft: 53,000
Paxil: 66,000
Fluvox: 2,900
Celexa: 220SSRI acetylcholine binding values:
Prozac: 445
Zoloft: 5,800
Paxil: 720
Fluvox: 8,900
Celexa: 3,100http://www.erowid.org/chemicals/ssris/ssris_info1.shtml
Trimipramine is awful! Is it really worth the negative effects on learning to get to sleep when other sleep aids exist? I really can't present a more logical argument than what follows. I just don't understand why people don't care. An antidepressant should show cognitive benefits.
There is a "possible correlation between the reduction in LTP expression and learning deficits produced by chronic administration of trimipramine."http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8476377&dopt=Abstract
"Taken together the present data suggest that the loss of LTP maintenance in TRIM-treated animals is more likely the result of the disruption by trimipramine of cellular processes that follow LTP induction. In addition, the results provide evidence for a possible correlation between the reduction in LTP expression and learning deficits produced by chronic administration of trimipramine."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8476377&dopt=Abstract
"Whereas the binding characteristics of various agonist and antagonist ligands to the N-methyl-D-aspartate and the AMPA receptors were not modified by trimipramine treatment, there was a significant reduction in the increase in 3H-AMPA binding elicited by PLA2 treatment. Since activation of PLA2 has been reported to play a critical role in the formation of long-term potentiation, possibly mediated through a modification of the AMPA receptors, the results strengthen the hypothesis that PLA2-induced modification of 3H-AMPA binding is an important component of synaptic plasticity."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7912839&dopt=Abstract
poster:Shawn. T.
thread:113043
URL: http://www.dr-bob.org/babble/20020718/msgs/113102.html