Posted by fachad on July 20, 2002, at 17:07:44
In reply to trimipramine, posted by katekite on July 20, 2002, at 12:23:53
Both Trimipramine and Benadryl have anti-histamine and anti-cholinergic properties.
The anti-histamine effects cause drowsiness, improved sleep, reduced allergic reaction.
The anti-cholinergic effects cause drying, dry mouth, dry eyes, constipation.
Most anti-histamines also have anti-cholinergic effects, so people tend to think of anti-histamines as drying. But they are only drying to the extent that they have anti-cholinergic effects.
For example, Remeron is an extremely potent anti-histamine, with a binding affinity of 700, but with little to no anti-cholinergic activity. It is extremely sedating, but not drying.
Just to give a scale, Benadryl histamine binding affinity is about 7. It's 100 times less potent than Remeron. But it has enough anti-cholinergic activity to be very drying.
Trimipramine has an histamine affinity of 370.
> Can anyone who's taken trimipramine say how they felt it compared with Benadryl as far as the anti-histamine effect goes: was it somewhat drying? Did you notice dry eyes at all? Gummy mouth?
>
> If so did that effect go away or not?
>
> Thanks -- Kate
poster:fachad
thread:113043
URL: http://www.dr-bob.org/babble/20020718/msgs/113079.html