Posted by JonW on June 16, 2002, at 10:35:11
In reply to Re: Please send me a bill! Thanks! » JennyJen, posted by JohnX2 on June 16, 2002, at 8:51:20
> symptoms. Now we just need a med w/o all the dietary crud!
Just an FYI that there is some evidence that suggest Parnate + Reboxetine could be a beneficial combination in this regard. I'm curious why there haven't been any other studies since 1994, but here's the one to which I'm referring:
(http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7931221&dopt=Abstract)
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Reboxetine prevents the tranylcypromine-induced increase in tyramine levels in rat heart.Dostert P, Castelli MG, Cicioni P, Strolin Benedetti M.
Farmitalia Carlo Erba, Research and Development, Erbamont Group, Milan, Italy.
This study aimed to examine whether the increase in heart radioactivity levels after intravenous injection of 14C-tyramine to rats pretreated with the irreversible MAO inhibitor tranylcypromine could be antagonized by reboxetine, a potent and selective noradrenaline uptake blocker. Reboxetine was found totally to abolish the effect of tranylcypromine. Heart radioactivity levels after reboxetine and tranylcypromine were very similar to those found when tyramine was injected after reboxetine only. These results suggest that reboxetine might be advantageously combined with tranylcypromine, or any MAO inhibitor, in depressed patients unresponsive of either treatment given alone.
PMID: 7931221 [PubMed - indexed for MEDLINE]
--------------------------------------------------Jon
poster:JonW
thread:110022
URL: http://www.dr-bob.org/babble/20020609/msgs/110039.html