Posted by Anna P. on June 1, 2002, at 23:55:20
In reply to Re: Acamprosate Calcium/Lisa Simpson » Anna P., posted by SLS on May 31, 2002, at 8:27:41
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> Hi Anna.
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> For what condition are you interested in trying acamprosate (Campral, Aotal, Zulex)?>>> Hi Scott,
I'm interested in trying Acamprosate for my cyclothymia, treatment-resistant depression and poop-out of the medications. I had a miracle response for the combination of Moclobemide and Revia (Naltrexone) that lasted for about six months, than faded. I found out about Naltrexone thanks to this site.
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> From what I can tell, it might be a good drug for bipolar disorder, perhaps bipolar depression in particular. I guess I should try to get more specific details of what this drug does. I know that it prmotes GABA activity and lowers NMDA activity. Lamictal, which seems to possess true antidepressant properties, also lowers NMDA activity, albeit via different mechanisms. Neurontin and Depakote promote GABA activity, so perhaps acamprosate would exert both mood-stabilizing and antidepressant effects. I'm glad you decided to post this. I have been interested in a NMDA antagonist drug sold in Germany known as memantine (Akatinol). About a year ago, AndrewB, who hasn't posted in some time, reported that his addition of memantine to his antidepressant regime prevented his becoming tolerant to Adderall, an amphetamine. Previously, Adderall would work for only three days at a time before pooping-out all together. He would cycle on and off of it to experience this transient improvement. Andrew claimed that memantine prevented the development of tolerance to Adderall, and he was able to maintain a steady and persistent improvement.<<< Scott, I've read about AndrewB's experience.
I'm interested in Memantine as well.
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> I'm pretty sure that memantine is being developed in the US for use in Alzheimer's dementia and perhaps Parkinson's. However, it is used in Germany for depression as well. Maybe I should consider trying acamprosate as a substitute. My problem is that when a drug coaxes my brain to work properly, my brain fights back and defeats the drug after only three days of remission. This 3-day thing has occurred with TCAs, MAOIs, nomifensine, bromocriptine, and amphetamine. The 3-day number seems to appear with others as well. I wonder if acomprosate or memantine would prevent the development of "tolerance" to antidepressants in the same way as it did so with amphetamines for AndrewB. Is this what you had in mind?
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> Thanks.
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> - Scott
>>> Yes,Sott, that's what I was hoping too. Are you ready to try either Acamprosate or Memantine?
Are you shure they use Memantine in Germany for depression as well? I'm just wondering if they have energizing or sedating effect.
Please let me know how are you doing.
Anna P.
poster:Anna P.
thread:44789
URL: http://www.dr-bob.org/babble/20020525/msgs/108394.html