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Does Lamictal 'blunt' the effects of Dexedrine?

Posted by 3 Beer Effect on April 4, 2002, at 23:27:18

I take what is considered a high dose of Dexedrine 20 mg for ADD & Social Phobia an hour before work on an empty stomach, & don't drink anything acidic- I just drink water all day.

As posted before I take 'Dextrostat' instead of Dexedrine because it is the same thing (dextroamphetamine) but is available in 10 mg tablets. Dextrostat is a name brand & not generic dextroamphetamine (although it is cheap- 32 cents per 10 mg tablet) & is made by the makers of Adderall (Shire), so i'm ASSUMING it is of equal efficacy as an equal amount of Dexedrine which is only available in 5 mg tablets.

Anyways & more importantly, in every psychopharmacology textbook i've ever read they say 20 mg of Ritalin= 10 mg of Dexedrine. So far, it seems that even 20 mg of Dextrostat/Dexedrine is weaker than Ritalin 20 mg, which doesn't make much sense. I also take Lamictal as an anti-depressant which I am now at 125 mg and am titrating to 150 mg tommorow night (I find it sedating rather than activating- couldn't tolerate any other anti-depressants). Along with the Lamictal I take 2 mg/day of Klonopin for social phobia & 2 mg at night for sleep.

It seems to me that the Lamictal may be blunting the effects of the Dextrostat? Doesn't Lamictal act as a mood-stabilizer by putting a ceiling & a floor on dopamine & norepinephrine levels, so the Dextrostat is unable to break through the "dopamine ceiling" & thus doesn't work very well? I know that Lithium basically cancels out the actions of amphetamines. Is Lamictal anti-dopaminergic? Before, I started Provigil & Lamictal at the same time about 2 months ago, & the Provigil seemed to lose effectiveness more & more as I raised the Lamictal dose.

I also noticed that before I started taking any anti-depressants, benzos, or any other psychiatric drugs that when I took 20 mg of Ritalin or 20 mg of Adderall, which is pretty similar to Dextrostat/Dexedrine- they both worked great & I even raised my GPA from a 2.2 to a 3.0.
Now the 20 mg of Dextrostat I take doesn't seem anywhere near as strong as 20 mg of Adderall or 20 mg of Ritalin. Any thoughts or ideas/explanations on why the Dexedrine/Dextrostat at this high dose isn't working very well or of any interactions between Lamictal or Klonopin & amphetamines? The only stimulant stronger than Dexedrine is supposed to be Methamphetamine (desoxyn)!

(My original plan was to take 10 mg of Dextrostat in the morning to study & 10 mg for work in the evening, but this isn't possible due to the lack of efficacy so far of even 20 mg at once).




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