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Re: SAM-e Oddity.

Posted by colin wallace on March 23, 2002, at 15:53:55

In reply to Re: SAM-e Trial » JohnX2, posted by Ron Hill on March 23, 2002, at 15:11:39

I'm really at a loss to explain this (I've been experimenting for a few weeks now to be entirely certain), but when I SPLIT a Sam-e (enteric coated)pill, I actually get a significantly greater antidepressant response than I do when taking the entire pill.I'm not just talking about immediacy, which would perhaps be explicable in terms of SOME Sam-e reaching the brain quicker than it otherwise would have, had the absorption been via the intended intestinal route.I mean, simply, a noticably better/quicker/sustained antidepressant response.
This I will concede, is entirely implausible, as Sam-e is NOT well absorbed through the stomach; indeed, all empirical evidence suggests that it is actually destroyed in the stomach (hence the need for an enteric coating).
I cannot even hazard a guess as to what's occurring here- any theories are most welcome.

Afterthought:
As I delve deeply into the vaguaries of memory,I recall reading an article explaining that l-tryptophan was a poor supplemental choice, due to seratonin mechanisms being somehow used and (seratonin) being abstracted by the stomach prior to reaching the brain; 5htp supplements circumvented this problem, instantly crossing the blood/brain barrier (excuse the blurred science here, this is dredged up from an equally blurred memory).
Any connection here?I'll admit, I'm fumbling in the dark, and will duly go and do some research!!


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poster:colin wallace thread:98301
URL: http://www.dr-bob.org/babble/20020322/msgs/99676.html