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Re: How to treat neuropathic pain ? pleae help

Posted by JohnX2 on March 26, 2002, at 5:20:41

In reply to Re: How to treat neuropathic pain ? pleae help » ben, posted by Zo on March 26, 2002, at 4:40:54


Neurontin from what I hear is almost the gold standard for neuropathic pain? I used it to bat off tingling from tapering off a medication. I used 300 mg 3x a day (but tapered up to that).

Hmm, I saw this abstract recently indicating that Wellbutrin may be useful for peripheral neuropathy???? I'm pretty sure it won't sedate you. Might make you dizzy. Never heard of this one besides this abstract however...

John

1: Neurology 2001 Nov 13;57(9):1583-8 Related Articles, Books, LinkOut


Double-blind, randomized trial of bupropion SR for the treatment of neuropathic pain.

Semenchuk MR, Sherman S, Davis B.

Department of Neurology, University of Arizona, Tucson 85743, USA. Marilyn.R.Semenchuk@gsk.com

OBJECTIVE: To evaluate the effectiveness and safety of bupropion sustained-release (SR) for the treatment of neuropathic pain. METHOD: This single-center, outpatient, randomized, double-blind, placebo-controlled, crossover study consisted of two phases. Forty-one nondepressed patients with neuropathic pain spent 6 weeks in each phase in random order and received identical tablets of 150 mg bupropion SR or placebo. Patients were instructed to take one tablet once daily for 1 week followed by one tablet twice daily for 5 weeks. RESULTS: While the patients took bupropion SR, neuropathic pain relief was improved or much improved in 30 (73%) patients, and one of these patients became pain-free. The mean average pain score at baseline was 5.7, which remained unchanged at the end of week 6 with placebo, but decreased by 1.7 points to 4.0 (p < 0.001) during therapy with bupropion SR. Pain relief with bupropion SR was significant at week 2 (p < 0.05) and continued throughout weeks 3 through 6 (p < 0.001). A significant decrease in interference of pain on quality of life was observed while patients were receiving bupropion SR compared with placebo. Side effects experienced with bupropion SR were not dose-limiting and consisted primarily of dry mouth, insomnia, headache, gastrointestinal upset, tremor, constipation, and dizziness. CONCLUSION: This placebo-controlled crossover trial showed that bupropion SR (150-300 mg daily) was effective and well tolerated for the treatment of neuropathic pain.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 11706096 [PubMed - indexed for MEDLINE]

> Neurontin is a *great* help, but you have to start small, be very very patient, and ramp up SLOOOOWLY, to get to a therapuetic dose that does not put you in a coma. I did it, for FM pain--which it seems to have cured, hasn't come back in a year. But you have to be willing to go thru some fog for the first month. . .which does lift. . .
>
> Zo


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poster:JohnX2 thread:99846
URL: http://www.dr-bob.org/babble/20020322/msgs/100237.html