Posted by JohnX2 on March 4, 2002, at 0:34:48
In reply to Re: Wellbutrin increases or decreases dopamine? » JohnX2, posted by Jill K. on March 3, 2002, at 22:33:50
Jill,
I don't know what Desipramine does.
But I'll give you 2 more examples.Almost EVERY atypical antipsychotic that
blocks the serotonin 5ht-2 receptor has absoltutely NO
affinity for the dopamine reuptake pump yet
substantially INCREASES dopamine
in the (pre)frontal cortex of the brain.
Why, because there are a lot of indirect mechanisms
of action that occur in this complex machine
we call the brain. In the frontal cortex it has
been widely shown that the serotonin 5ht2 receptor
is negatively coupled to dopamine release (i.e.
it is a gate keeper for dopamine release). This
is also true in other areas of the brain.Example 2, Nicotine has absolutely no affinity
for the dopamine reuptake pump, etc, yet increases
concentrations of dopamine via an indirect mechanism
in the limbic (feel good) portion of the brain.There are a lot of indirect routes to increase
dopamine conductance.Best regards,
John> Desipramine is also very effective for ADHD, and it effects norepinephrine, not dopamine. Many people on desipramine also report an amphetamine like feeling. So I am not sure if this correlates with wellbutrin increasing dopamine.
>
poster:JohnX2
thread:96141
URL: http://www.dr-bob.org/babble/20020301/msgs/96268.html