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Re: My experiences with Provigil other stims

Posted by Rick on February 22, 2002, at 17:37:14

In reply to Re: My experiences with Provigil other stims » kregpark@yahoo.com, posted by manowar on February 22, 2002, at 12:24:33

Re Ray's idea for Tim, I wonder if MAOI's are safe with Provigil (modafinil) or adrafinil. The manufacturer says the combo hasn't been tested, and I recall reading one rodent study that reported at least indirect serotonergic effect of some sort from Provigil.

One reason I'm curious (besides wanting to see Tim experience the most consisitent benefit) is that, even though my current combo (Klonopin+Provigil+Serzone) works so well for my social phobia, I miss the memory-enhancing effect I seemed to get from Eldepryl/Deprenyl/selegiline. Since taking even a tiny dose with Klonopin added back some anxiety for me, I would try a super-tiny dose. From what I've read, a little bit of selegiline can have some potent and long-lasting effects.

(Of course I'd have to dump the Serzone -- the least important part of my combo -- even though it's only been *speculated* that MAOI+Serzone is dangerous, not actually demonstrated.)

Anyone out there taking/taken Provigil or Adrafinil + an MAOI? Ray, weren't you doing that at one time? Details, please?

Thanks,
Rick

----
> Hi Ray,
>
> I'm glad you mentioned the Eldepryl. I'm taking Adrafinil 600-1200 mg a day along with 300 mg a day of Wellbutrin (which I don't think is helping me), and 54 mg of Concerta once every two or three days. The Adrafinil (and Modafinil also) really seems to help my depression. However, even with the Adrafinil, I may do well for several days, then bam! - I'm in the funk again. Anergic, unmotivated, etc...
>
> When I start coming down with the funk, the next morning I add the 54 mg of Concerta to my chemical cocktail, and bam! - I'm out of the funk. I can't take the Concerta on a daily basis, or I'll quickly develop a tolerance (within two or three days).
>
> I was thinking about adding Eldepryl to my diet of drugs. Maybe the MAOI effects of the drug could continue to smooth out my Cyclothymia.
>
> Any suggestions by anyone would be very much appreciated.
>
> Tim
>
> > Ever tried using Eldepryl 5-10mg as a "base" (no pun intended), then adding the Provigil, Wellbutrin, or whatever?
> >
> > Eldepryl used alone that way synergizes quite potently (dopaminergically) in augmentation.
> >
> > Ray
> >
> > http://www.socialfear.com/
> >
> > > Hi,
> > > I thought some of you might find my experience with Provigil interesting (and maybe a little dull as well). First of all, I have depression (frequently quite severe) and usually find myself having varying degrees of anergia. I have tried Provigil in combination with Celexa, Wellbutrin, Effexor, Desipramine, and all alone. I have tried doses from 200-600mg/day. For me, any dose below 400mg is unnoticeable. Only when I have taken 600mg am I unable to fall asleep. At that dosage, the only other side effects I notice are perhaps a tiny (hardly noticeable) amount of shakiness and increased heart rate. No euphoria, no increased desire to socialize, nothing else at all. I do not think that my response is typical, but I suppose I'm one of the unlucky ones. I have also tried Adderall and Concerta (even in combination with Provigil) and neither of those are particularly stimulating for me either. Don't get me wrong, the Adderall and Concerta don't go unnoticed, they just don't have me bouncing off the walls. The largest effect that I notice with either of those is the increased ability to concentrate (although I have never been diagnosed ADD). No euphoria with those, either. In fact, the only stimulant that has ever had that kind of effect for me is cocaine, which I have only tried on one occasion. Another odd thing with my experience with coke is that it had me euphoric and wide awake for *hours* after only 1.5 lines (taken in one dose). I have stayed away from it ever since because I can see myself becoming quickly addicted. BTW, I've never had an addiction and definitely am not looking to start. Anyway, good luck with Provigil or whatever you pursue and I hope that you can find a medication that helps keep you happy!
> > >
> > > Adam


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