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Re: Dexedrine/Provigil Tolerance? IsoM

Posted by Ritch on February 16, 2002, at 21:35:59

In reply to Dexedrine/Provigil Tolerance? Elizabeth, posted by IsoM on February 16, 2002, at 19:53:29

> > > "...I've heard many positive stories about modafinil. The main complaint people seem to have is that it costs too much. It really isn't a great antinarcoleptic since it doesn't treat cataplexy; it's better for depression and ADD, IMO. The risk of tolerance to modafinil is probably not that different from the risk of tolerance to Dexedrine."
>
> Elizabeth, most people with narcolepsy don't experience cataplexy that often or as severe as it's sometimes dramatisised. Most of us just experience muscle weakness & trouble standing (tend to collapse unless sitting, then we keel over in the laughter or tears). Most of us find the most troubling aspect of narcolepsy is fighting the constant all-day sleepiness. That's why modafinil & adrafinil is so good. We can finally be productive without spending enormous effort at trying to stay awake & alert.
>
> The review I read of adrafinil done by CNS Reviews by a team at Toronto, said that even after 3 years or more of use, tolerance to adrafinil wasn't seen.
> http://www.nevapress.com/cnsdr/full/5/3/193.pdf
>
> I do know I could build tolerance to Dexedrine fairly quick when used continuously. I would give myself frequent drug holidays as what would once keep me alert soon lost its effect & would instead need an increase - something I wouldn't do, hence the drug holidays.


Hi IsoM,

When I increase dosages of SSri's I get the most hypomanic, but the weird thing is...I tend to have spells of laughter. Sometimes the laughter spells involve loss of consciousness (a few seconds). For example, if someone tells me a really good joke and I respond with some laughter I will see *spots* in my eyes and I will sometimes fall to the floor. Does this not sound like the *cataplexy* involved with narcolepsy??

Mitch


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