Posted by JohnX2 on February 9, 2002, at 20:50:04
In reply to Adderall is not working anymore., posted by George on February 9, 2002, at 6:04:58
Here are my ideas for medicines that may
help with the tolerance issue:medicine (mode of action)
- Lamictal (NMDA antagonism)
- Topamax (increased GabaA conductance)
- Memantine (NMDA antagonism)Lamictal + Topamax or Memantine + Topamax
combo may subtantially alleviate your tolerance.
There are a lot of papers that describe the
sensitization/tolerance pathway of stimulants and
most of them implicate NMDA and Gaba receptors.Unfortunately there is no substantial real world data
in this area, just anecdotal observations and some
shooting from the hip.- John
> I have been taking Adderall for a little over a year now and it has completely changed my life. I had suffered from uni-polar depression for many years, taken over twenty different antidepressants, and nothing worked. Then I took Adderall and almost overnight, everything changed. I had my life back. I took 40mg every other day, and this worked great for about 12 months. Then I had to go to 40mg every third day. Then 50mg every third day. Now, at 60mg it is hardly working at all, even with four or five days in between doses. I don't know what to do. I'm rather scared since this drug has been a godsend and other stimulants (concerta, provigil) have not worked at all. Can anyone give me any advice because my pdoc has provided no good answers. Thanks for your help.
poster:JohnX2
thread:93399
URL: http://www.dr-bob.org/babble/20020208/msgs/93518.html