Posted by Mr. Scott on January 27, 2002, at 19:58:45
In reply to Re: Prozac akathisia driving me nuts » Mr. Scott, posted by MB on January 27, 2002, at 19:27:38
> > You might be surprised...all SSRI's are NOT created equally.. Just my experience.
>
> My knowledge of anatomy is horrid, but I believe that there is a part of the brain (does "striatum" sound right?) that is innervated by both serotonergic neurons and by dopaminergic neurons. From what I understand, some of the serotonergic neurons in this region synapse onto the dopaminergic neurons in this region and have an inhibitory effect on the action of these dopaminergic neurons (causing decreased dopaminergic activity in this area and consequent akathisia). I need to find an SSRI that exibits less modulation of the serotonin pathways in the striatum(?). But the $10,000 question is which SSRIs have this property. I do believe that the akathisia is due to underactivity of dopamine (at leat somewhere, if not in the striatum) because dopamine enhancing drugs like Adderall help the akathisia.
>
> By the way, what the hell is a striatum anyway (LOL!!!)
>
> MBIf I run for president my campaign slogan will be "Nigro-striatal pathways rich with dopamine for all!"
Yes I believe your right about, dopamine, and movement, and the like. However recently I understand it is less clear whether it is too much or too little dopaminergic activity at a given site that causes the symptoms we're talking about and are characteristic of several movement disorders. Unfortunately we haven't gotten so far as to have such wonderfully selective chemicals as you describe. However, I do know that Zoloft has the most dopaminergic enhancing properties and then theres always effexor. But theories aside, I noticed akathesia on Prozac but not celexa, which is purpoted to be the most selectively serotonergic??
Oye Vey...It gets complicated..
Scott
poster:Mr. Scott
thread:91621
URL: http://www.dr-bob.org/babble/20020124/msgs/91811.html