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Re: Prozac akathisia driving me nuts

Posted by OldSchool on January 27, 2002, at 20:48:44

In reply to Prozac akathisia driving me nuts, posted by MB on January 25, 2002, at 21:11:46

> Even with Klonopin (2mg/day) and LARGE doses of Neurontin (400mg 5 x day) I'm still getting breakthrough akathisia from the Prozac I'm on. I'm also taking 5 mg of Adderall, but that actually *helps* the akathisia. I think the akathisia is from the the way prozac stimulates 5-HT(sub)2 receptors, which in turn antagonizes dopamine action in the striatum. Do you think that if I switched to Serzone (which blocks 5-HT(sub)2 receptors and hence increases striatal dopamine) I would have less akathisia? I've suffered Restless Leg Syndrom all my life and this exacerbation is driving me loony-toons.
>
> MB


Serzone and Remeron cause less akathesia definitely. You could also try adding OTC benadryl...that helps fight that sort of SSRI akathesia. Akathesia is believed to be from feeble dopamine activity. Anti-cholinergics like benadryl can help.

Ask your doctor though about taking benadryl if you are already taking Adderall.

Old School


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