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Re: Lamictal _is_NOT_ an antidepressant

Posted by kiddo on January 12, 2002, at 7:56:11

In reply to Lamictal _is_ an antidepressant » Denise528, posted by CalvaryHill on January 12, 2002, at 4:33:17

Lamictal is an Anti-epileptic drug (AED) and may be used as an Antidepressant. If you take it, you need to watch for a rash as well-and inform your doctor if you, as soon as it's noticed.


Kiddo


> Lamotrigine works on serotonin as an Antidepressant for unipolars, alleviating anxiety and depression, according to these and other studies:
>
> Southam E, Kirkby D, Higgins GA, Hagan RM. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
> Eur J Pharmacol. 1998 Sep 25;358(1):19-24:
> "The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake in vivo. These effects probably reflect an affinity for biogenic amine transporters..."
>
> Erfurth A, Amann B, Grunze H. Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?
> Neuropsychobiology. 1998 Oct;38(3):200-1:
> "The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake..."
>
> Kumar TC, Khanna S.
> Lamotrigine augmentation of serotonin re-uptake inhibitors in obsessive-compulsive disorder.
> Aust N Z J Psychiatry. 2000 Jun;34(3):527-8.
>
> Shiah IS, Yatham LN, Lam RW, Zis AP. Effects of lamotrigine on the 5-HT1A receptor function in healthy human males.
> J Affect Disord. 1998 May;49(2):157-62.


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