Psycho-Babble Medication | about biological treatments | Framed
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Posted by on January 6, 2002, at 8:36:05

In reply to Re: Provigil-Modafinil-Adrafinil? christophrejmc, posted by Rick on January 5, 2002, at 15:03:13

I saw a small study with selegiline open trial around 12 people completed I think. I read it, was inconclusive, no clearcut benefit but a few had good results and the rest unchanged.

I do think selegiline can be very useful for SP in augmention. I've tried it myself 5mg both alone and in combo.
This in spite of the fact that taken alone I also experience agitation, prosexual but generally unpleasant effect.
I do think Elderpyl can probide an excellent "base" to build on for both cases of SP which are dopaminergically responsive as well as bipolar low.

Actually I have long liked Eldepryl, but have chosen Nardil because it was just easier to work with so far, requiring less complicated combo (majority of my history is Nardil alone or Nardil + Klonopin, no other meds).

Amisulpride has been incredible so far at 25mg with my current regimen. I mentioned the possibility of Eldepryl due to so far noticing a lowered energy level, (Not surprising with my regimen). Provigil and/or W/B at high enough doses cause me hair loss so I've hestitated going higher there with my regimen for now. Other stimulants and MAOI's do not give me that problem. Energy is generally fine, but I don't have my previous level of desire to excercise and exert physically. Always into athletics and not the type to sit and watch TV, (maybe is better but ...) I am not fired up so much about physical exercise as I have always been before. Well it's just like AndrewB said, something like the "desire to grab the tiger by the tail" - I think I'm talking the same kind of thing - a more DA / NE base for amilsulpride might work better (probably at >25mg amisulpride).

I threw out the Elderpyl idea a bit early, I will not be changing anytime soon. Things are going well and I can work with and perhaps even simplify my current regimen.

To Andrew B:
Wanted to thank you for sharing your invaluable experiences, thoughts, ideas, opinion.
If not for your posts I wouldn't have known a thing about amisulpride and, crucially, so much insight into how to *use* amisulpride succesfully for dysthmia and social phobia.
There *is* some info on Medline for Dysthmia, but not for SP, and there is nothing really to "catch the eye" that amisulpride is the "med to go with" for Dysthmia.

Reading through all your posts I was able to catch enough of your insight to give it a shot, and though time will tell even 1 week has been so eye-opening!


> But the key here is that the amphetamine metabolites are likely *not* the cause of the anxiety selegiline produced. Instead -- despite the talk of dopamine deficiency in social phobia -- I find that dopaminergic agents in general make me a lot more anxious. And I'm not the only one...most attempts to harness dopamine for social phobia have been major failures, such as the selegiline study I mentioned as well as a pergolide study where the results were so negative that the study was quickly aborted.
> That doesn't mean dopamine enhancement can't play a role in social phobia treatment in some as-yet undetermined fashion. But dopamine's a complex and rather mysterious substance that can have diametrically opposing mental and physical (e.g., blood pressure modulating) impact at different binding sites, etc.
> do give selegiline a try, please let us know how it goes.
> Rick

> > Have you ever been on an amphetamine (Adderall, Dexedrine, Desoxyn)? If so, did it cause the same anxiety you experienced with selegiline? (As I'm sure you know, two of selegiline's metabolites are l-amphetamine and l-methamphetamine.)
> >
> > I'm considering trying selegiline for my depression & social phobia. (Amphetamines don't really increase my anxiety (in fact, sometimes they relieve it).)
> >
> > Thanks,
> > Christophre




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