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Re: Provigil-Modafinil-Adrafinil? christophrejmc

Posted by Rick on January 5, 2002, at 15:03:13

In reply to Re: Provigil-Modafinil-Adrafinil? Rick, posted by christophrejmc on January 5, 2002, at 14:15:53

Christophre

No, never been on amphetamines. The selegiline metabolites are the closest I've come.

But the key here is that the amphetamine metabolites are likely *not* the cause of the anxiety selegiline produced. Instead -- despite the talk of dopamine deficiency in social phobia -- I find that dopaminergic agents in general make me a lot more anxious. And I'm not the only one...most attempts to harness dopamine for social phobia have been major failures, such as the selegiline study I mentioned as well as a pergolide study where the results were so negative that the study was quickly aborted.

That doesn't mean dopamine enhancement can't play a role in social phobia treatment in some as-yet undetermined fashion. But dopamine's a complex and rather mysterious substance that can have diametrically opposing mental and physical (e.g., blood pressure modulating) impact at different binding sites, etc.

If you do give selegiline a try, please let us know how it goes.

Rick

> > Even a tiny dose that I later used to (successfully) offset slight Klonopin-induced dulling added back some anxiety.
>
> Have you ever been on an amphetamine (Adderall, Dexedrine, Desoxyn)? If so, did it cause the same anxiety you experienced with selegiline? (As I'm sure you know, two of selegiline's metabolites are l-amphetamine and l-methamphetamine.)
>
> I'm considering trying selegiline for my depression & social phobia. (Amphetamines don't really increase my anxiety (in fact, sometimes they relieve it).)
>
> Thanks,
> Christophre


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