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Re: selegiline patch vs. oral » Cam W.

Posted by Elizabeth on December 30, 2001, at 17:07:20

In reply to Re: selegiline patch vs. oral (Cam?) » Elizabeth, posted by Cam W. on December 29, 2001, at 13:55:37

Cam --

If it were just a matter of first-pass metabolism, wouldn't you expect that a high enough dose of oral selegiline (Eldepryl) would work as well as the patch?

> As an aside, the only really interesting fact I do remember about selegiline is that 2 of its 3 major metabolites are amphetamine and methamphetamine. I wonder how much these contribute to its use in the psychiatric field.

Two of the metabolites of selegiline (which is itself an l- isomer) are l-amphetamine and l-methamphetamine, which I'm given to understand have more peripheral and less central activity than the d- isomers.

-elizabeth


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poster:Elizabeth thread:87632
URL: http://www.dr-bob.org/babble/20011222/msgs/88269.html