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Re: selegiline patch vs. oral (Cam?) spike4848

Posted by Elizabeth on December 29, 2001, at 6:27:19

In reply to Re: selegiline patch - responses some people's ?s, posted by spike4848 on December 28, 2001, at 22:03:39

> Please correct me if I am wrong .... I though I had read some posts in the past where people responded to the patch but found oral selegiline not as effective? Or do I have it backwards, that most people who respond to the patch do equally as well on oral medications?

Maybe Cam can come up with an explanation. Here're my thoughts, though, FWIW:

I think that people who find oral selegiline less effective might not be taking a high enough dose. I can't see why else there would be a problem. Sometimes drugs are absorbed very poorly orally compared to parenterally, and as a result the oral dose must be much higher than the parenteral one (morphine is a good example -- thirty years ago or so, it was thought that morphine wasn't orally active at all).





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