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Provigil Olmifon (adrafinil) vs Stims

Posted by IsoM on December 22, 2001, at 13:36:58

In reply to Re: Why Provigil, Why not Ritalin or Amantidine?, posted by on December 22, 2001, at 12:26:08

I don't have social phobia but do HATE being around people when depressed - I don't particularily like people then.

But in using adrafinil & previously Ritalin & Dexedrine, adrafinil wins hands down for me. I never would've realised how good it was if I hadn't tried it. It didn't just help my problem staying awake but a number of other things bugging me that I'd never expected it to affect.

> Provigil is much more site specific in the brain, and probably (indirectly) effects primarily serotonin and dopamine, both increased.
> Ritalin and amantidine both induce more anxiety than Provigil.
> I've trialed both. I found that amantadine lended itself better to long term use than Ritalin due to less anxiety, agitation, anger, and a long half. Definite energy increase noticable on day 1 and sustained over 5 week trial. Also was prosexual but I noticed that this effect didn't occur until week 2 or 3 - rare for me to get such a delayed (no pun :) response. Unfortunately it increased SP symtoms (unlike Provigil).
> I've also used Ritalin, but the short half life was troublesome leading to rebound depression and constant (Xanax like) dosing. The SR version is only a slight improvement. In addition Ritalin is a potent norepinephrine agonist as well, and with me and probably most others with SP will (in regular use) excerbate SP symtoms (again unlike Provigil).
> Still, as with most dopamine agonists, those 2 meds might be helpful for some, particularly in more complicated polyphamacy (ie; add xanax, amisulpride (low dose), risperidone/zyprexa (low dose)).
> I don't believe I've heard of *any* people with SP successfully using amantadine or Ritalin in long term treatment of SP. On this board I have seen a lot of posts of improvments with adrafinil ande\ modafinil (Provigil) - pretty impressive I think considering there is essentially NO research on either of these meds for the treatment of Social Phobia or fear in general.
> kp
> > Question about provigil? I am aways a bit leary of new medications .... never know what the long term side effect profile will be. What is the difference between provigil and standard dopamine agonists like ritalin or amantidine. Provigil is soooooo expensive.
> >
> > Spike




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