Posted by shelliR on November 23, 2001, at 0:12:47
In reply to Re: Morphine for depression. » shelliR, posted by SLS on November 19, 2001, at 10:59:55
>Hi Scott.
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> How do you deal with the roller-coaster ride every day? It must be difficult to have your state of being be so immediately tethered to a drug? It's not like taking a regular antidepressant where you can miss a few doses or take it at your convenience without feeling significantly worse. I'd be grateful to take it and have it work, though. It must be emotionally taxing just the same.
The roller-coaster ride is only once a day in the morning and I think that would have been finally disappeared. In the beginning oxycontin stimulated me too much to take it at night at all, and then I woke up with horrible depression. Once I had gotten myself up to 1/2 dose at bedtime the magnitude of the depression was lower. I think eventually I could have tolerated a full dose at night and the morning roller coaster would be allievated. The afternoon dose had some overlap, so it was not noticable.I think that methodone may be different in this respect. Once it gets into my body after a few days, it is supposed to last longer, so I may stil have enough of my evening dose still in me to avoid the depression.
As much as I hate waking up depressed in the morning and having to wait for an hour with the depression, I do have to admit that every morning, I had the most wonderful feeling flow through me during the transition. But I am aware that the change in my body is totally connected to a drug (as you stated "tethered to a drug"). This is a bit unsettling, but probably similar to the feeling of waking up with anxiety and waiting for a benzo to work. It is not, as you pointed out, similar to taking a AD,where is easily able to escape taking notice of the cause and effect (depression/pill/lack of depression)
> Do you think nausea or feeling wierd are predictors of non-response? I found something on the Internet that described that most people using methadone for depression begin to experience improvements by the end of the first week. Some took two weeks.Do you remember where you found that on the internet?
I think Elizabeth has more experience with this since she did have to adjust to buprenorphine, while I did not have to adjust at all to vicidin or oxycontin. I loved them both from the first time. .Today was different than yesterday with the methadone--I think although I took the same dose, it may have been too much. I don't feel as good, and I am having difficulty focusing. When I say didn't feel as good, I am not talking about depression, that is gone, but my body doesn't feel as well, and I may try to go down in dose tomrrow. I have to be somewhat more patient; this is a new drug for me. And yes, Elizabeth might be correct concerning a possible need to adjust and that one bad day is not enough to tell.
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> At my last visit, I was happy to see that he was somewhat receptive to the possibility that opioids might be worth considering. I mentioned oxycodone and buprenorphine. I didn't know about methadone at the time.Receptive enough to let you give it a try, or is he still pretty far away from that? If you want to try it you might want to push harder so you can figure out if this guy might really go in that direction. Also, it is still best to stay on an anti-depressant with an opiate to avoid the dramatic ups and downs if possible, and potentially ly cut down on tolerance. (I'm not sure about that one).
Take care,
Shelli
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poster:shelliR
thread:84007
URL: http://www.dr-bob.org/babble/20011113/msgs/84952.html