Posted by Mitch on November 7, 2001, at 9:57:23
In reply to Vivid Evidence of Provigil Anti-Anxiety Effects, posted by Rick on November 6, 2001, at 19:16:24
> Despite these caveats, today’s episode just reinforces for me what a godsend Provigil is for my Social Phobia, at least in combo with the other meds.
>
> I heard today that importer Cephalon announced record earnings this year based on Provigil. This is despite the failure to show clinical significance in the initial placebo-controlled ADD trial, which had been deemed a major blow to the company. (This may have been related to the way the study was done; I’ve heard they’re continuing to test for this indication based on some very favorable anecdotal evidence.) If they can do this well despite the ADD setback, it’s clear that off-label uses of this med must be exploding, and patients must be responding. (How else could such a high-priced drug drum enough usage to drive up earnings? Certainly not from the relatively small number of people with narcolepsy, the official indication). Unfortunately, I have a feeling anxiety disorders won’t be among any of of the investigated uses anytime soon. (Although benefits in this area may surface as use of Provigil for AD augmentation accelerates, given that AD’s are often prescribed for non-depressive anxiety.) Right now some of the possible focus areas seem to be AD Augmentation, ADD/ADHD. Sleep Apnea, Parkinson’s, and Alzheimer's (not sure if the latter is still under active consideration), and Multiple Sclerosis-induced fatigue (looks very promising here).
>
> RickRick,
Interesting discussion there about Provigil. I have mixed social anxst and attention problems. I notice that a lot of episodes of social anxiety happen at work when I am 'surprised' by a conference call. NOBODY tells me diddly-squat about it, of course-the phone just rings and there are half a dozen others on the other end sitting around a speaker-phone God knows where. One of those events happened just last week and I had to shift gears suddenly and try to remember what the hell they were trying to ask me...I just paused started to hem/haw and then I felt the panic starting to hit me. Finally, I just told them to summarize what the hell they were wanting, from who, and for what reason and send that to me in an email and then I would get back to them! Our salesperson involved was pissed, but I had to get out of that, my head was just mush. I wonder if a lot of social anxiety I experience is directly related to ADHD symptoms?
Anyhow, isn't Provigil an adrenoreceptor *agonist*?? Also, what role could it play in Parkinson's? I have seen posts about it, but most seemed to be thumbs-down stuff in relation to successful AD augmentation for TRD. What are the most common side-effects?
Mitch
poster:Mitch
thread:83383
URL: http://www.dr-bob.org/babble/20011104/msgs/83425.html