Posted by Mitch on October 10, 2001, at 13:25:03
In reply to Re: Remeron - Worse first and then better?, posted by SLS on October 10, 2001, at 11:32:35
> > Maybe you can try Mianserin if Mirtazapine-like pharmacology is what you are looking for.
>
>
> I've decided not to continue with Remeron until I speak to my doctor. What I described as a worsening of depression is definitely not sedation. I think it might actually be the NE alpha-2 blockade that is responsible for this. I had the same negative reaction to idazoxan, an experimental NE alpha-2 antagonist devoid of antihistaminic properties.
>
> I took 7.5mg of Remeron about 1:00am. When I woke up at 8:00am, I thought I was feeling somewhat improved. I immediately became optimistic and was excited that it hadn't made me feel worse. I assumed that everything was going my way. There was to be no self-fulfilling prophecy here. However, by 12:00pm noon, I was significantly worse. I slept all day to escape it.
>
> Now, I don't know what to do.
>
> I appreciate all of the constructive feedback. Thanks.
>
>
> - ScottScott,
When I was taking Remeron something similar happened as well. I would have trouble getting up, but once I was awake and two strong coffees to the wind I was fairly active and felt fairly decent. THEN, about four or five hours after I woke up I would get these "head rushes" of dizziness and then just become somnolent and just want to couch potato the rest of the day. It could have been the caffeine dropping out, but hell I can't drink coffee every hour! I wonder if instead of the alpha2 antagonism maybe it is the other NE receptor that is implicated with orthostatic hypotension causing the trouble?
Mitch
poster:Mitch
thread:80829
URL: http://www.dr-bob.org/babble/20011007/msgs/80876.html