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Re: Zyprexa and Serotonin ??? SalArmy4me

Posted by SLS on September 28, 2001, at 11:50:22

In reply to Re: Zyprexa and Serotonin ??? Janelle, posted by SalArmy4me on September 28, 2001, at 1:11:40

> Zyprexa works best in combination with Prozac treatment (for depressive states), and on norepinephrine as well as dopamine.
> The American Journal of Psychiatry. Volume 158(1) January 2001 pp 131-134. A Novel Augmentation Strategy for Treating Resistant Major Depression
> "With fluoxetine treatment, norepinephrine and dopamine levels increase to 188% and 143% of baseline values, respectively. However, when both fluoxetine and olanzapine are given, norepinephrine and dopamine levels increase to 269% and 349% of baseline values, respectively. This suggests a neurochemical basis for the synergistic antidepressant effect observed in the present trial. The prefrontal cortex is rich in mesocorticolimbic dopamine innervation (21-23). Coupled with the well-chronicled role of norepinephrine in mood states (24), this suggests potential targets for treating resistant depression..."

Hi Sal.

Do you think using Zyprexa in combination with Prozac is better than using it combination with any of the other SSRIs?


- Scott




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