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Re: Zyprexa and Serotonin ??? Janelle

Posted by SalArmy4me on September 28, 2001, at 1:11:40

In reply to Zyprexa and Serotonin ???, posted by Janelle on September 27, 2001, at 21:58:37

Zyprexa works best in combination with Prozac treatment (for depressive states), and on norepinephrine as well as dopamine.

The American Journal of Psychiatry. Volume 158(1) January 2001 pp 131-134. A Novel Augmentation Strategy for Treating Resistant Major Depression

"With fluoxetine treatment, norepinephrine and dopamine levels increase to 188% and 143% of baseline values, respectively. However, when both fluoxetine and olanzapine are given, norepinephrine and dopamine levels increase to 269% and 349% of baseline values, respectively. This suggests a neurochemical basis for the synergistic antidepressant effect observed in the present trial. The prefrontal cortex is rich in mesocorticolimbic dopamine innervation (21-23). Coupled with the well-chronicled role of norepinephrine in mood states (24), this suggests potential targets for treating resistant depression..."




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