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Re: BefloxaGONE (Most Effectve Med For Soc Phobia) » SLS

Posted by Rick on August 28, 2001, at 21:53:02

In reply to Re: BefloxaGONE (Most Effectve Med For Soc Phobia), posted by SLS on August 28, 2001, at 21:09:45

> > >
> > > To me the most exciting news is the phase II (or is it III) trials of the reversible (no food restrictions, ostensibly low-side-effect) MAOI befloxatone. So far it is reported to be about as effective as Nardil, and much more effective than the currently=marketed reversible MAOI moclobemide.
> > >
> > > Rick
> >
> > Unfortunately, my info was a little out of date. I found out after posting that befloxatone was abandonded late last year, when Phase III trials for depression failed to show clinically significant results.
> >
> > Rick
>
>
>
> *^$#!
>
> What was your source of information? I had planned to call Sanofi tomorrow. A doctor Palumbo was supposed to be directing the project. Damn.
>
>
> - Scott

The 9/18/2000 issue of R & D Focus Drug News says:

"Sanofi-Synthelabo announced at a company presentation in London, UK, that its selective and reversible monoamine oxidase A inhibitor, befloxatone (MD 370503), is no longer in active development. This oxazolidone derivative was being evaluated as a treatment for depression and smoking cessation in Europe and the USA. The company stated that no significant beneficial effect was achieved in phase III studies for either indication."

Also, if you go to Sanofi's website and download the 2000 annual report, you'll see it listed as one of the three development-discontinued drugs, no explanation given.


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