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Re: Amoxapine » Elizabeth

Posted by Sunnely on June 28, 2001, at 0:29:06

In reply to Re: Amoxapine » Sunnely, posted by Elizabeth on June 27, 2001, at 12:20:31

Technically speaking, amoxapine (Asendin) is classified as an antidepressant. Amoxapine, which is a demethylated metabolite of the antipsychotic drug loxapine (Loxitane), has classic neuroleptic activity, so its use eventually included, aside from depression per se, also psychotic depression, as you mentioned. This avoids combining the use of an antidepressant and an antipsychotic for patients with psychotic depression or schizoaffective disorder, depressed. Similar to other antipsychotics with D2 blocking effect, it carries with it a full range of extrapyramidal side effects - acute dystonic reactions, akathisia, pseudoparkinsonism, and tardive dyskinesia.

***************************

> > Not only that amoxapine (Asendin) reported to cause acute dystonia, it has also been reported to cause tardive dyskinesia (TD). Any doctor or prescriber choosing this drug as a first line treatment for depression, when newer safer antidepressants are available, is asking for a malpractice suit.
>
> Woah! Nobody said amoxapine should be a first-line treatment for depression. What it should be considered for is *psychotic* depression.
>
> -elizabeth


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