Posted by Elizabeth on June 27, 2001, at 12:22:09
In reply to Re: Maprotiline (Ludiomil):, posted by Salilyn on June 26, 2001, at 5:06:31
> Asendin is another drug, in my opinion, that's best left forgotten. In the early to mid-80's, my psychiatrist used it as an antidepressant, and as an antipsychotic (in his schizophrenic patients). Its antipsychotic properties, I think, are due to its dopamine-blocking action. I stopped it within several days because of its side effects, which can include extrapyramidal symptoms (e.g., dystonia).
I didn't get any EPS on amoxapine -- I stopped because of appetite increase (I'm such a chicken about that). You're right that it's a D2 receptor antagonist, but the rate of EPS is lower than it is with conventional antipsychotics. It seems like a reasonable choice for psychotic depression, in particular. (All the antipsychotics in current use are dopamine antagonists. They *all* have the potential to produce EPS and TD.)