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Serzone + Dopamine Agonist = Serotonin Syndrome?

Posted by joema on June 25, 2001, at 14:35:30

I'm a 43-yr old male with a 4mm prolactin-secreting benign pituitary tumor called a prolactinoma. I take 0.5mg/week of a dopamine agonist med called Dostinex (Cabergoline), which controls my prolactin level and prevents the tumor from growing.

I also have mild depression/anxiety, for which I'm trying various ADs. When I took 150mg of serzone, within 2 hrs I had hypomania, diaphoresis, shivering, 102 temp, nausea, blurred vision, marked flu-like symptoms. It gradually abated over 24 hr.

Are there known drug interactions between dopamine agonists and Serzone? Did I have serotonin syndrome, or just individual sensitivity to a (maybe too high) starting dose?

Can I start at a much lower dose of serzone (say 20 mg), and just very slowly increase? Are there risks to doing this given the above?

-- joema


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poster:joema thread:67835
URL: http://www.dr-bob.org/babble/20010625/msgs/67835.html