Posted by Cam W. on June 2, 2001, at 0:10:05
In reply to Re: EFFEXOR POOP-OUT ??? Anyone - Bad and Good Stories, posted by SLS on May 31, 2001, at 8:04:09
> Now comes the fun part. What are some possible mechanisms by which a drug could produce a long-term change in psychobiological function so as to promote a depressive vulnerability or treatment-resistence?
>
> You first. :-)
>Scott - Hmmm...Structural changes to neuronal pathways/circuitry (eg altered synaptic pruning) or changes in input or output of various subcortical nuclei or structures (eg changes in hippocampal serotonin output or changes to neuropeptide release in the hypothalamus). Perhaps second messenger changes or alterations in protein/enzyme release.
This is a really tough question because of the complexity of interactions between systems and also the plasticity of the neural circuitry. Also we cannot exclude environmental changes and its effects on circuits and systems.
Going through the scientific data in this area is like building a 100,000 piece car from a 1,000,000 different pieces. For example, I have a blue wire and a red wire; I know what wires do, but what, if any, is the significance of this wire? Is being blue important or is it an arbitrary artifact? Does it even belong in the car?
BTW - The car example hits rather close to home. I just picked up my car from the garage ($600.31 later). I trust the mechanic implicitly and if it wasn't him that did the work, I'd really wonder why my car needs a $277.00 harmonic balancer. Sounds like its aura wasn't right and they had to exorcise it.
I think this topic is too big for either of us right now, but in ten years the answers will seem so obvious. Go figure. - Cam
poster:Cam W.
thread:64575
URL: http://www.dr-bob.org/babble/20010530/msgs/65134.html