Posted by Cam W. on May 30, 2001, at 9:21:02
In reply to Re: EFFEXOR POOP-OUT ??? Anyone - Bad and Good Stories, posted by SLS on May 30, 2001, at 7:42:51
Scott - Because of the 5-HT2A block with Zyprexa, I would think that Zyprexa may actually worsen serotonergic withdrawl syndrome, to a small extent. The withdrawl syndrome is thought to occur because of a sudden withdrawl of serotonin. The best way to treat this state is to slowly remove the serotonin to allow the body to either re-adjust its neurotransmitter complement or to (hopefully) prod the body into increasing the amount of serotonin it produces (or probably a mixture of both).
Scott, I've just had a radical thought on antidepressants and the progression from a reactive depression to a chronic depresssion. This is most definitely "thinking out loud", as it just occurred to me while typing the above post. Hopefully you have some comments on this.
There has been some discussion over the years on cold medicines. Decongestants, like pseudoephedrine and phenylpropranolamine, draw body water into the sinuses to get the mucus (snot) moving. Antihistamines, like chlorpheniramine and bromopheniramine, dry out the sinus lining once the mucus has drained. Some scientists have shown that taking these products, which only treat the symptoms of a cold, actually prolong the cold by tricking the body into thinking that cold is clearing. Thus the body doesn't mount as strong of an attack against the virus and the cold lasts longer than it normally would. Hey, maybe Grandma was right, and lots of fluids (pee off the bug) and bed rest (let the body heal itself) are the best way to treat a cold.
Let's take this a step further to antidepressants (esp. SSRIs). Could antidepressants cause a reactive depression, which, if not too severe, to change to a chronic depression? My theory being that the artificial increase in serotonin causes the body to slow down natural serotonin production. If left long enough, could this possible decrease in natural serotonin be maintained after the antidepressant is removed, thus setting the person up for a relapse. I have not thought this through, yet, but what do you think?
Damn, I hate my overactive brain, sometimes. Looking forward to hearing from you. Your buddy in the bizarre workings of the mind. - Cam
poster:Cam W.
thread:64575
URL: http://www.dr-bob.org/babble/20010530/msgs/64723.html