Posted by Mitch on June 1, 2001, at 23:17:07
In reply to Re: Serotonin receptor downregulation???, posted by loosmrbls on June 1, 2001, at 13:45:35
FWIW, I think that bottom-line is getting the serotonin receptor density DOWN. I just wonder if there is a more complex method that is yet undiscovered (DNA-wise) that would reduce the serotonin receptor density *directly*, not *indirectly* as how the brain does it now as a response to AD's.
> If the theory is that there is not enough serotonin in the synapses, I would expect an INCREASE in post-synaptic serotonin receptors to try and compensate for lack of neurotransmitter.
>
> Than, all of a sudden you give a drug where there is an increase in serotonin in the synapse, and you still have an increase in receptors. It probably takes a few days for the receptors to decrease, so for a few days you actually have over-stimulation of the serotonin pathways.
>
> However, I still can't figure it all out. I would think if you increase serotonin, the body would decrease it;s sensitivity to it as an adjustment and you'd be back at square one. However, as you know it gets much more complicated than that -- there are receptors on both sides of the synapse and I truly think it's all guesswork what will finally work.
>
> For me, I think the Depakote does provide some stabilization by acting as a generalized nervous system depressant (calms it down). I'm not sure exactly what the antidepressant is doing positive, but it does bring about immediate agitation that is counter-acted by the benzo. Maybe I should stop these two.
>
> However, lithium does not have an antidepressant effect on me. And I'm prone to depression if not on an antidepressant. So should I take Neurontin instead of Remeron/Klonopin?
>
> Another problem is the Klonopin sometimes makes me feel goofy, almost works TOO well. I sure wouldn't mind stopping the Remeron. In combination with Depakote, I've gained some weight.
poster:Mitch
thread:64595
URL: http://www.dr-bob.org/babble/20010530/msgs/65126.html