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Re: Serotonin receptor downregulation???

Posted by loosmrbls on June 1, 2001, at 13:45:35

In reply to Serotonin receptor downregulation???, posted by Mitch on June 1, 2001, at 13:34:25

If the theory is that there is not enough serotonin in the synapses, I would expect an INCREASE in post-synaptic serotonin receptors to try and compensate for lack of neurotransmitter.

Than, all of a sudden you give a drug where there is an increase in serotonin in the synapse, and you still have an increase in receptors. It probably takes a few days for the receptors to decrease, so for a few days you actually have over-stimulation of the serotonin pathways.

However, I still can't figure it all out. I would think if you increase serotonin, the body would decrease it;s sensitivity to it as an adjustment and you'd be back at square one. However, as you know it gets much more complicated than that -- there are receptors on both sides of the synapse and I truly think it's all guesswork what will finally work.

For me, I think the Depakote does provide some stabilization by acting as a generalized nervous system depressant (calms it down). I'm not sure exactly what the antidepressant is doing positive, but it does bring about immediate agitation that is counter-acted by the benzo. Maybe I should stop these two.

However, lithium does not have an antidepressant effect on me. And I'm prone to depression if not on an antidepressant. So should I take Neurontin instead of Remeron/Klonopin?

Another problem is the Klonopin sometimes makes me feel goofy, almost works TOO well. I sure wouldn't mind stopping the Remeron. In combination with Depakote, I've gained some weight.


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poster:loosmrbls thread:64595
URL: http://www.dr-bob.org/babble/20010530/msgs/65048.html