Posted by Cam W. on May 24, 2001, at 9:10:05
In reply to Re: Extreme edema: call pdoc asap » mvaureen, posted by Sulpicia on May 24, 2001, at 0:54:34
> >
> > I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?
>
> Hi--
> I don't know if this link is going to work -- oh damn. It's late here..
> The point here is that edema can be a sign of a allergic reaction to the wellbutrin, and a potentially serious one.
> Can your pdoc or clinician and report it.
> Now.
> Feel better soon.
> S.
> Browse Alphabetically
> A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
>
>
>
>
>
>
>
>
> Bupropion HCl
>
>
> (byoo-PRO-pee-ahn HIGH-droe-KLOR-ide)
>
>
> Action
> Indications
> Contraindications
> Route/Dosage
> Interactions
> Lab Test Interferences
>
> Adverse Reactions
> Precautions
> Patient Care Considerations
> Administration Storage
> Assessment/Interventions
> Patient/Family Education
>
>
> Trade Name(s):
>
> Wellbutrin
>
> Tablets, 75 mg
> Tablets, 100 mg
>
> Wellbutrin SR
>
> Tablets, sustained-release, 100 mg
> Tablets, sustained-release, 150 mg
>
> Zyban
>
> Tablets, sustained-release, 150 mg
>
> Indicates Canadian trade names.
>
> Class: Antidepressant/Smoking deterrent
>
>
>
> Action:
>
> Exact mechanism of antidepressant activity or as a smoking deterrent
> unknown; does not inhibit monoamine oxidase.
>
>
>
> Indications:
>
> Treatment of depression; aid to smoking cessation treatment.
>
>
>
> Contraindications:
>
> Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa;
> concurrent treatment with or within 14 days of discontinuation of MAO
> inhibitors; concurrent treatment with multiple bupropion products (eg,
> coadministration of Zyban for smoking cessation and Wellbutrin for
> depression).
>
>
>
> Route/Dosage:
>
> Antidepressant
> Adults: PO 100 mg bid initially; may increase to 100 mg tid after 3 days.
> Maximum daily dose 450 mg; maximum single dose 150 mg.
> Sustained release: 150 mg daily initially; may increase to 150 mg bid.
> Maximum daily dose 400 mg; maximum single dose 200 mg.
>
> Smoking Deterrent
> Adults: PO Initial dose: 150 mg for first 3 days increasing to 150 mg bid.
> Do not give doses > 300 mg/day. Initiate treatment while patient is still
> smoking. Patient should set target date to quit smoking within the first 2
> weeks of treatment; continue treatment for 7 to 12 weeks. Maintenance:
> Clinical data is not available regarding long-term treatment ( > 12 weeks)
> for smoking cessation. Whether to continue treatment must be
> determined for individual patients. Combination treatment: Combination
> treatment with bupropion and nicotine transdermal system may be
> prescribed for smoking cessation.
>
>
>
> Interactions:
>
> Carbamazepine: May decrease bupropion serum concentrations.
>
> Ritonavir: May increase bupropion serum concentrations increasing risk of
> toxicity.
>
> MAO inhibitors, selegiline: May increase risk of acute bupropion toxicity.
> Discontinue MAO inhibitors ≥ 14 days before starting bupropion.
>
> TCAs: TCA plasma concentrations may be elevated.
>
>
>
>
>
>
> Adverse Reactions:
>
> CNS:
> Abnormal thoughts; agitation; anxiety; depression; insomnia;
> irritability; hallucinations; somnolence; suicidal ideation; seizures;
> headache/migraine; tremor; nervousness; memory decreased;
> paresthesia; CNS stimulation; increased libido.
> CV:
> Edema; chest pain; flushing; hypertension; hot flashes; stroke;
> tachycardia; vasodilation; ECG abnormalities (eg, premature beats,
> nonspecific ST-T segment changes); MI.
poster:Cam W.
thread:64065
URL: http://www.dr-bob.org/babble/20010522/msgs/64100.html