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Re: Extreme edema: call pdoc asap mvaureen

Posted by Sulpicia on May 24, 2001, at 0:54:34

In reply to Extreme edema, Effexor withdrawal or Wellbutrin?, posted by mvaureen on May 23, 2001, at 23:58:19

>
> I need to know if anyone is familiar with extreme swelling of the lower legs, fingers, ankles during withdrawal from Effexor or starting Wellbutrin. I'm have terrible pain in my legs and ankles. I can't wear my shoes anymore. What on earth can be causing this?

Hi--
I don't know if this link is going to work -- oh damn. It's late here..
The point here is that edema can be a sign of a allergic reaction to the wellbutrin, and a potentially serious one.
Can your pdoc or clinician and report it.
Now.
Feel better soon.
S.
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Bupropion HCl


(byoo-PRO-pee-ahn HIGH-droe-KLOR-ide)


Action
Indications
Contraindications
Route/Dosage
Interactions
Lab Test Interferences

Adverse Reactions
Precautions
Patient Care Considerations
Administration Storage
Assessment/Interventions
Patient/Family Education


Trade Name(s):

Wellbutrin

Tablets, 75 mg
Tablets, 100 mg

Wellbutrin SR

Tablets, sustained-release, 100 mg
Tablets, sustained-release, 150 mg

Zyban

Tablets, sustained-release, 150 mg

Indicates Canadian trade names.

Class: Antidepressant/Smoking deterrent

Action:

Exact mechanism of antidepressant activity or as a smoking deterrent
unknown; does not inhibit monoamine oxidase.

Indications:

Treatment of depression; aid to smoking cessation treatment.

Contraindications:

Seizure disorder; current or prior diagnosis of bulimia or anorexia nervosa;
concurrent treatment with or within 14 days of discontinuation of MAO
inhibitors; concurrent treatment with multiple bupropion products (eg,
coadministration of Zyban for smoking cessation and Wellbutrin for
depression).

Route/Dosage:

Antidepressant
Adults: PO 100 mg bid initially; may increase to 100 mg tid after 3 days.
Maximum daily dose 450 mg; maximum single dose 150 mg.
Sustained release: 150 mg daily initially; may increase to 150 mg bid.
Maximum daily dose 400 mg; maximum single dose 200 mg.

Smoking Deterrent
Adults: PO Initial dose: 150 mg for first 3 days increasing to 150 mg bid.
Do not give doses > 300 mg/day. Initiate treatment while patient is still
smoking. Patient should set target date to quit smoking within the first 2
weeks of treatment; continue treatment for 7 to 12 weeks. Maintenance:
Clinical data is not available regarding long-term treatment ( > 12 weeks)
for smoking cessation. Whether to continue treatment must be
determined for individual patients. Combination treatment: Combination
treatment with bupropion and nicotine transdermal system may be
prescribed for smoking cessation.

Interactions:

Carbamazepine: May decrease bupropion serum concentrations.

Ritonavir: May increase bupropion serum concentrations increasing risk of
toxicity.

MAO inhibitors, selegiline: May increase risk of acute bupropion toxicity.
Discontinue MAO inhibitors ≥ 14 days before starting bupropion.

TCAs: TCA plasma concentrations may be elevated.


Adverse Reactions:

CNS:
Abnormal thoughts; agitation; anxiety; depression; insomnia;
irritability; hallucinations; somnolence; suicidal ideation; seizures;
headache/migraine; tremor; nervousness; memory decreased;
paresthesia; CNS stimulation; increased libido.
CV:
Edema; chest pain; flushing; hypertension; hot flashes; stroke;
tachycardia; vasodilation; ECG abnormalities (eg, premature beats,
nonspecific ST-T segment changes); MI.


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poster:Sulpicia thread:64065
URL: http://www.dr-bob.org/babble/20010522/msgs/64070.html