Posted by medlib on May 15, 2001, at 18:25:19
In reply to Re: NON-SSRI Antidepressants?, posted by JohnL on May 15, 2001, at 5:28:02
My pdoc says that Effexor affects NE reuptake significantly at doses above 200mg. and DE (weakly), above 300mg. Once you reach your optimum level of Effexor, if you feel something more is needed, you might consider "adding back" a small amount of Wellbutrin. Since Wellbutrin may affect NE and DE receptors in a manner other than reuptake, the combo (W + E) may be more than the sum of its parts. Obviously the usual caveats apply--go slow, check with your pdoc, YMMV; but a few Babblers have found success with that combo, I believe. You could check the Archives, if interested. Few people here find adequate relief with a single med; many of us require 3 or more to get back to ground zero.