Posted by Maniz on March 31, 2001, at 16:34:18
In reply to Re: good scientific article on adrafinil/modafinil, posted by AndrewB on March 31, 2001, at 11:39:56
Hi AndrewB, thanks for your comments
> Maniz,
>
> Thank you for posting this excellent article on adrafinil. Finally some solid information on it!Yes, maybe sometime Lafon puts some info on the site they are building.
>I don't think I was the only one who was leary of this med. due to the lack information on it.sure, and we still lack substantiated information on side effects
>I particularly noted the article's substantiation of the long-term safety and effectiveness it appears to have. The article also confirms that it is an arousal and motivational agent that does not disturb sleep or cause anxiety. It seems to improve mood in many. It was my hunch that this med was a centrally acting alpha 1 agonist via glutaminergic actions. While the article makes the same speculation, clearly its exact mechanisim of action is unclear.
What do you know about glutamate excitotoxicity?. I read about it in many websites but I am not sure how it works. It seems that calcium gets into the cells, bla bla...
Do you think adrafinil can be neurotoxic?. I do not want to risk my poor neurons for just a temporary lift.
I do not know if adrafinil can be combined with neuroprotective substances. I have read magnessium conteracts calcium influx into the cell and also the drug nimodipine. Vinpocetine is also said to be anti excitotoxic. I am not sure if the commbination will help or just block the action of adrafinil.
> Some people feel tension or overstimulation on this med, I wonder if these people already have normal or hyperglutaminergic activity.
Well, I used to be very nervous but now it seems all my enery dissapeard and I am more inhibited than I used to be, especially regarding social situations. I do not know if this is depression or what but I do not want to take ADs.
> Also adranifil seems to have some differences in action between it and modafinil. First hand accounts indicate this also. Interesting that adrafinil has another metabolite besides modafinil though this does not necessarily explain their differences. I didn't understand the article's discussion on how sleep structure is changed. Was the implication that adrafinil can restore healthy sleep structure in those who have disturbed sleep structure?I think so, but I would have to read the article again to tell the truth, it was long...
>
> BTW, it is interesting that the combo of aniracetam and adrafinil was beneficial to you. Aniracetam I believe increases glutaminergic activity in the hippocampus,I did not know that about aniracetam.
> a structure involved with memory. What specific improvement did you see with this med combo. Maniz?
well, a bit more alert, easy to do things and talk (action and communication I might say).
But I am not taking the combo on a regular basis so I am not sure. Besides, the adrafinil dose was very low and the aniracetam was passed the expiry date. Anyway, I think I got a better effect than from either alone. I will certainly try again.
I read about other noradrenaline agonists (or whatever they are):
amineptine
reboxetineand maybe also wellbutrin
Do you know anything about them?. Can they be taken on low doses?.
Maybe they are safer and better than adrafinil if what we need is a noradrenergic.
Thanks and sorry for any inconsistence I am just trying to learn.
Please comment on this if you can.
poster:Maniz
thread:57729
URL: http://www.dr-bob.org/babble/20010327/msgs/58229.html