Posted by AndrewB on March 31, 2001, at 11:39:56
In reply to good scientific article on adrafinil/modafinil, posted by Maniz on March 27, 2001, at 22:39:20
Maniz,
Thank you for posting this excellent article on adrafinil. Finally some solid information on it! I don't think I was the only one who was leary of this med. due to the lack information on it. I particularly noted the article's substantiation of the long-term safety and effectiveness it appears to have. The article also confirms that it is an arousal and motivational agent that does not disturb sleep or cause anxiety. It seems to improve mood in many. It was my hunch that this med was a centrally acting alpha 1 agonist via glutaminergic actions. While the article makes the same speculation, clearly its exact mechanisim of action is unclear. Some people feel tension or overstimulation on this med, I wonder if these people already have normal or hyperglutaminergic activity. Also adranifil seems to have some differences in action between it and modafinil. First hand accounts indicate this also. Interesting that adrafinil has another metabolite besides modafinil though this does not necessarily explain their differences. I didn't understand the article's discussion on how sleep structure is changed. Was the implication that adrafinil can restore healthy sleep structure in those who have disturbed sleep structure?
BTW, it is interesting that the combo of aniracetam and adrafinil was beneficial to you. Aniracetam I believe increases glutaminergic activity in the hippocampus, a structure involved with memory. What specific improvement did you see with this med combo. Maniz?
AndrewB
poster:AndrewB
thread:57729
URL: http://www.dr-bob.org/babble/20010327/msgs/58212.html