Posted by noa on November 5, 2000, at 10:17:11
In reply to Re: Brain Serotonin Receptors in Depression , posted by R.Anne on November 4, 2000, at 15:29:14
Thanks John. I am trying to understand this. Maybe you can help. Some thoughts/questions:
It doesn't say whether the depressed patients were on long term AD therapy or not, and whether that could affect the numbers of 5HT2 receptors.
If SSRIs and some other ADs end up making more serotonin available, this includes both 5HT1 and 5HT2, yes?
For me, it seems 5HT2 is the source of the adverse side effects I get on SSRIs and Effexor (agitation, activation, insomnia, myoclonus, restlessness, etc.).
Those effects are lessened significantly by Serzone, which, I believe, Blocks 5HT2 receptors.
Some people get the opposite effects on SSRIs and effexor--ie, they get sleepy, rather than sleepless.
Do you think that the difference between me and them could be the number of 5HT2 receptors? Ie, do you think I would not fit the pattern of the depressed group in the study?
poster:noa
thread:48194
URL: http://www.dr-bob.org/babble/20001102/msgs/48240.html