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Re: High doses of Parnate-SLS?

Posted by Judy on October 22, 2000, at 14:10:26

In reply to Re: High doses of Parnate, posted by SLS on October 21, 2000, at 18:30:50

Hi Scott,
Long time no see. Last time I was here, you were very helpful to me with suggestions for augmenting Parnate when I had to quit my beloved Nardil because of the side effects. By the way, you were absolutely right about the ability to achieve orgasm returning after several months. What you didn't mention, or maybe this is only in my case, is that even if the mechanics return to working order, you don't really care.

I'm still taking Parnate alone (with Xanax at night to get about 5 hours of sleep). None of the combinations I've tried (lithium, thyroid, estrogen) made an appreciable difference, so I read with interest this thread about higher doses. I'm taking 70 mg per day right now and have just got the go-ahead to try 80 although my doctor didn't seem to think it would make any difference in my mood. So I was particularly curious about your statement:

>I have come across some research studies that indicate that Parnate begins to do things at high dosages that it does not do at lower dosages that are unrelated to MAO inhibition.

Can you be a bit more specific about that in layman's terms? Good things or bad things? I have no clue what deregulation means to me.

I just saw my doctor last week and he agreed that, for me, Parnate is "as good as it's going to get." I don't respond to anything but MAOI's and Nardil and Marplan have been ruled out because of the severe edema, myoclonus , and other nasty physical side effects they began to cause. That's pretty upsetting since I'm tolerating Parnate relatively well and I'm not really depressed but I am apathetic and anhedonic and I can't deal with accepting the way I feel right now as the best it's ever going to be.

Please translate for me your understanding of what you've read about taking higher doses of Parnate.





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