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Re: High doses of Parnate

Posted by SLS on October 21, 2000, at 18:30:50

In reply to High doses of Parnate, posted by Steeler Tookahn on October 21, 2000, at 11:38:47

Hi Steeler.

I have taken as much as 150mg of Parnate in combination with 300mg of imipramine. I have also taken Parnate 120mg + desipramine 200mg + Dexedrine 15mg + T4 thyroid. While already taking Parnate 120mg, I have added nortriptyline, imipramine, and Wellbutrin seperately.

I think you will be able to get a good feel for how safe and effective the high-dosage Parnate strategy can be by referring to Dr. Bob's Psychopharmacology Tips.

I have come across some research studies that indicate that Parnate begins to do things at high dosages that it does not do at lower dosages that are unrelated to MAO inhibition. One such effect is the downregulation of 5-HT2 receptors, something that occurs with several other antidepressants. Unlike Nardil, Parnate has been shown to produce a decrease in dopamine D2 receptor densities.

Jay Amsterdam, MD, has used high-dosage Parnate treatment for difficult cases for at least 10 years. Some people have needed as much as 300mg per day.

Good luck.

- Scott




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