Posted by Sigolene on October 1, 2000, at 9:19:46
In reply to Re: to amisulpride users, posted by JohnL on October 1, 2000, at 8:25:49
Jhon,
> The chimestry question is complicated. I'm trying to think what to try next, if amisulpride is not working. But this time i really don't know.
I want to treat depression first, social phobia, CFS and poor concentration, insomnia.
I can forget all the serotoninergic meds, they worsen my depression.
Regarding the NE meds, i don't know what to think because for example Ludiomil was effective on my atypical depression, but too much sedation and side effects. Then i tryed logically an other NE med less sedating: Reboxetine. But instead of improving my mood, it worsened it ! So i really don't understand anything with NE active medications.
I never had Ritalin because in Europe they don't give it easily. I also never had mood stabilizator (lithium, tegretol,...) because i'm not manic and i don't like to take too many different meds.
Well, now in possession of all this informations, do you have a suggestion ?
(in Europe we also don't have Burpropion, it's a shame)
Sigolene.> Sigolene,
>
> If I were you, I would give it one more week. If you haven't improved dramatically (not just a little) by then, then I would stop it. It merely indicates that whatever chemistry is causing your problems, Amisulpride is not targeting it.
>
> Amisulpride can indeed work in a week or less. With me I can feel it the first day even. That indicates that whatever chemistry is causing my troubles, Amisulpride is right on target. With you, there could likely be a different chemistry at fault. Amisulpride could still work through a domino chain reaction kind of effect, like anything else if given enough time, but the fact that it has done nothing so far indicates to me that it is nowhere close to being on-target with you.
>
> So if it doesn't work and you must switch to something else, what to try next? Have you tried 2 or 3 SSRIs? If so, that would indicate that serotonin is not the chemistry at fault. Tricyclics like Desipramine or Nortriptyline? They are often the best, but have more side effects. They target norepinephrine chemistries. Adrafinil? This would target your norepinephrine chemistry, with few side effects.
>
> And there is a chance your troubles aren't caused by a neurotransmitter deficiency at all. If that's the case, then a small dose of either Lithium (chemical smoother), or Depakote (electrical smoother) or Tegretol (electrical smoother) could be on target. Or maybe your transmitters are at good levels, but for some reason are failing to function properly...patchy performance, inadequate blood flow, etc. If that's the case, then you'll find dramatic improvement with Ritalin or Adderall.
>
> I don't know your history, so I'm just posing the different scenarios you face. Hopefully some clues can be put together and it will make more sense. Amisulpride could indeed work well if given more time. But the fact that it hasn't worked yet raises questions.
> John
poster:Sigolene
thread:45579
URL: http://www.dr-bob.org/babble/20000926/msgs/45595.html