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Wellbutrin and MAOI - safe combo? - please advise

Posted by Angela5 on September 20, 2000, at 2:03:00

My pdoc is considering putting me on an MAOI, but is unsure if Wellbutrin would be safe concurrently or if a waiting period would be necessary.

I know that it is not recommended to take Wellbutrin with an MAOI, but I am pretty sure that I have read about it being done, and my pdoc remembers prescribing it a long time ago with no bad results.

I only have a very, very basic knowledge of the pharmacology of all this stuff, but I know that reboxetine is safe with MAOIs (and in some studies has shown to lessen the hypertensive crisis risk). If I remember correctly, reboxetine works on noradrenaline. Since Wellbutrin works on noradrenaline (and weakly dopamine), I was reasoning that it would be safe also, i.e. no risk of serotonin syndrome. However, I'm not sure by what different mechanisms these drugs actually "work" (again, sorry for the poor understanding), so I don't know if my reasoning has any merit.

Hopefully this made sense - any advice would be most welcome!






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