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Re: Wellbutrin and MAOI - safe combo? - please advise

Posted by Sunnely on September 21, 2000, at 23:09:42

In reply to Wellbutrin and MAOI - safe combo? - please advise, posted by Angela5 on September 20, 2000, at 2:03:00

> My pdoc is considering putting me on an MAOI, but is unsure if Wellbutrin would be safe concurrently or if a waiting period would be necessary.


Hi Angela,

The Product Information (PI) of Wellbutrin SR (bupropion hydrochloride) clearly indicates the following CONTRAINDICATIONS with the use of Wellbutrin:

1. Wellbutrin SR is contraindicated in patients with a seizure disorder.

2. Wellbutrin SR is contraindicated in patients treated with ZYBAN (bupropion hydrochloride) or any other medications that contain bupropion because the incidence of seizure is dose dependent.

3. Wellbutrin SR is contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa because of a higher incidence of seizures noted in such patients treated with the immediate-release formulation of bupropion.

4. The concurrent administration of Wellbutrin SR Tablets and a monoamine oxidase (MAO) inhibitor is contraindicated. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with Wellbutrin SR Tablets.

5. Wellbutrin SR is contraindicated in patients who have shown an allergic response to bupropion or the other ingredients that make up Wellbutrin SR Tablets.




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