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Re: Question for AndrewB/Reboxetine augmentation

Posted by AndrewB on August 18, 2000, at 17:45:29

In reply to Question for AndrewB/Reboxetine augmentation, posted by Anna P. on August 14, 2000, at 13:06:13

Anna,

My personal experience is that there is no problem combining rebox., amisulpride and neurontin. I had a liver test recently and it came out ok, for what that is worth. I don’t think either reboxetine or amisulpride present a risk of liver toxicity when taken alone or in combo with other drugs. It is my layman’s impression that reboxetine has no identified significant interactions with other psychiatric agents.

When you say you had a partial AD response to neurontin/rebox., are you referring to the transitory response of improved mood and energy you had with neurontin? Is the reboxetine only providing improved arousal? How has the rebox. made you feel. How has the neurontin made you feel recently.

I had a short period of improved mood and energy on neurontin. I think Dr. Bobs Tips section also notes similar responses to neurontin. Some would say such a response is induced mania.

Of course, the question with you is whether your initial responses and poop out to a wide variety of ADs indicates an induction of mania and, therefore, prolonged AD response will not come before effective mood stabilization is achieved.

Dr. Goldstein on his website notes that energy improvement when taking neurontin is common with his CFIDs patients. He ascribes this to the fact that neurontin is an indirect NMDA antagonist. He notes that lamotrigine (another mood stabilizer----- did you already try that one?) and neurontin is often an effective combo. He apparently has had the best results with ketamine nasal spray, an NMDA receptor antagonist, for glutamate hyperactivity induced mood and energy deficits. I wonder whether a transitory positive response to neurontin would indicate that ketamine nasal spray may be effective. Anyway, you may want to check out his site or give his office a call. http://www.drjgoldstein.com/frames/05artbook.html

One final note, never combine two agents with a potential sedative (inhibatory) effects except with extreme caution. This includes alcohol and neurontin, lorazepam and alcohol, and so on. To combine a novel combo of sedative agents and go for a drive is of course a big No No. Anyway, it sounds like you have learned this lesson the hard way. I am so very glad you are alright. I’ve said this before, possibly to your displeasure, but I would feel more comfortable for you (Yes, you scare me) if you trialed your med combos in closer coordination with a qualified psychopharmocologist.

Best wishes ,

AndrewB


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URL: http://www.dr-bob.org/babble/20000811/msgs/43259.html