Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re:JohnL

Posted by JohnL on August 16, 2000, at 4:51:58

In reply to Re:JohnL, posted by Anna P. on August 15, 2000, at 11:16:27

I will consider SAM-e, but are you shure that neuroleptic can be combined with mood stabilizer? That scares me a little.

....Sure they can be combined. Psychiatrists mix all kinds of weird things. Neuroleptics+mood stabilizers isn't weird at all. The main thing to be aware of is that one or the other med might increase the blood levels of the other. So a reduced dosage of one or the other, or both, would be wise just to be safe. I'm not concerned with various combinations, but rather with how they affect blood levels of ongoing medication. For example, let's say you are taking 100mg of XYZ. Then you add another med. If the second med interferes at all with the meabolism of XYW (it almost surely will, but how much we don't know), then that 100mg of XYZ may accumulate to a blood level of perhaps 125mg or 200mg or whatever. It's metabolism and elimination is slowed down by the second drug, and thus accumulates. Did you know that adding a tricyclic antidepressant to an SSRI can increase the blood levels of the SSRI anywhere from 2 to 9 times? In any combination, that is my main concern...dosage adjustment.

Also, I read in your earlier post you mention some internet site for combinations with reboxetine.

....I was browsing doing research on Reboxetine some time ago, and sure enough, there have been studies combining Rebox with SSRIs and other meds. It has been and is being done.

What do you think about reboxetine combined with SNARI such as venlafaxine? Plus Neurontin of course.

....I don't see any problem with that, especially if Effexor was a low dose. It would primarily work on serotonin at a low dose. At a high dose its NE reuptake might be too much in light of the fact that Rebox is already doing that.

But I have to admit, if the hefty dose of Rebox you are already taking isn't working all that well, that you need to consider an add-on, then I would question if NE deficiency is even a concern in your case. That's why I tend to feel a gut instinct of looking at something that works from a totally different chemistry angle...like SAMe or Amisulpride. Effexor will sort of in a way just kind of be the same as things you're already doing, have done. But SAMe or Amisulpride would attack your symptoms from a brand new completely different angle, and likely be much more complimentary to your ongoing REbox/Neurontin. Am I making any sense?
John
>
> Anna P.
> > Anna,
> >


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:JohnL thread:42844
URL: http://www.dr-bob.org/babble/20000811/msgs/43046.html