Posted by JohnL on June 17, 2000, at 17:52:50
In reply to Doesage of Adrafinil (JohnL or AndrewB), posted by Lynne on June 17, 2000, at 0:32:06
Quite a discussion going on here. Pretty cool. I couldn't resist jumping in, since I'm pleasantly familiar with all the topics being discussed here.
Anyone trying Adrafinil should not expect anything for at least two weeks. Four is better, six even better. Contrary to my usual belief pattern, Adrafinil really does require time. It has an accumulating effect. The messy analogy I made in another post is that it's like throwing handfuls of spaghetti at the wall. Some of it will stick, some of it will fall to the floor. Keep throwing until the whole wall is covered. That really takes at least two weeks in my experience. Longer is better. (in case you're wondering, no, I've never thrown spaghetti at the wall :-))
Concerning Amisulpride, sources of information vary a little bit. But basically I think the turnaround pivot point is in the 250mg to 300mg range. That's where its mechanism reverses. I don't know though, based on symptoms and side effects Andrew talked about a while ago, I think I experienced that pivot mechanism at 100mg. Who knows.
Concerning SJW, 2700mg does seem like a lot. I mean, it was used in clinical trials at that dose with few side effects. But at that dose I get agitation sortof side effects. My optimum dose is the 1200mg range, though recently I've only been taking 300mg once every other day. That doesn't seem like much, but I do notice in a negative way when I stop taking it.
One observation I've made with SJW is that it seems to have a lot more ooomph when combined with something else, like Prozac, Adrafinil, Amisulpride, or whatever (but NOT Paxil! stay away from that combo). SJW seems to me to have a nice synergy with other things. But not all other things. Definitely not Paxil. If used as monotherapy, I really do think the recommended dose is way too low. One study indicated 300mg of SJW is roughly the same as 10mg of a tricyclic. Based on that, 5 to 8 pills a day seems to be in the right ballpark. And as was mentioned, brands that have minimum %hyperforin are good ones. Like 3%, 4%, 5%. There's even a new brand called New Chapter that has 10%hyperforin designed to be dosed once daily. I personally don't like the brands that have other ingredients mixed in, because then it's hard to tell what's doing what.
For me anyway, Adrafinil with a little SJW ended my very prolonged multiyear anhedonic melancholic depression. I had one more trick up my sleeve to try in place of Adrafinil, and it's working great. But, that's another post for another day...
JohnL
poster:JohnL
thread:35977
URL: http://www.dr-bob.org/babble/20000610/msgs/37654.html